Conformationally restricted dinucleotides: tandem ring-closing metathesis and hydrogenation approach.
نویسندگان
چکیده
Cyclic dinucleotides with saturated connections between a nucleobase and the phosphate are synthesised using a tandem ring-closing metathesis (RCM) and hydrogenation protocol and found to be significantly stabilised towards ammonia.
منابع مشابه
Bi- and tricyclic nucleoside derivatives restricted in S-type conformations and obtained by RCM-reactions.
Ring-closing metathesis (RCM) is applied as a new and powerful technology in the construction of nucleoside analogues that are conformationally restricted in S-type conformations due to additional 3',4'- and/or 3',5'-linkages.
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عنوان ژورنال:
- Nucleosides, nucleotides & nucleic acids
دوره 22 5-8 شماره
صفحات -
تاریخ انتشار 2003